Gene Expression Changes of Serotonin Receptors, 5-HT3AR and 5-HT2AR, in Breast Cancer Patients

Breast cancer is a serious and potentially lethal disease among 40-50 aged women and its incident rate is one out of eight in the United States and one out of thirty five people in Asia. Incidence of breast carcinoma is 10 per 100,000 of population with 7000 new cases annually in Iran. The age specific rate in females is 23.16/100,000. Every year 1200 women die due to breast carcinoma with burden of 0/31 DALY/1000, which is the third in ranking of burden of disease (BOD) among women and seventh rank in both sexes. It is expected that the number of new cases will rise up to 20,000,000 by 2015 globally and 12,000,000 deaths annually 70% of which will occur in developing countries (Akbari et al., 2011; Haghighat et al., 2012). It is a multi-factor disease, genetically mutation and environmental condition plays important role in the breast cancer (Madigan et al., 1995). Only 5-10 percent of the breast cancer patients have a known mutation and about 70% of breast cancer patient are not related to genetically mutation. The breast cancer is